Microglial activation and adult neurogenesis after brain stroke

Microglial Activation – Tuning and Pruning Adult Neurogenesis

NEW NEURONS ARE CONTINUOUSLY GENERATED IN TWO ADULT BRAIN REGIONS: the subgranular zone of the hippocampus and the subependyma by the lateral ventricles, referred to as the neurogenic niches. During their development from neural stem cells to mature functionally integrated neurons numerous choices are made, such as proliferation or quiescence, cell survival or death, migration or establishment,...

Microglial Cell Activation Neurogenesis by Negative Regulation of TAM Receptors Affect Adult Brain

Neurogenesis in Adult Brain

The idea that the adult brain retains the capacity to generate new neurons has been proposed several times over the last 40 years, and in each case both conceptual and technical constraints have led to resistance. Joseph Altman first reported that some dividing cells in the adult brain survived and differentiated into cells with morphology similar to neurons using tritiated thymidine autoradiog...

Cortical neurogenesis in adult rats after reversible photothrombotic stroke.

Neurogenesis occurs throughout life in the dentate gyrus of hippocampus and subventricular zone, but this phenomenon has rarely been observed in other brain regions of adult mammals. The aim of the current study was to investigate the cell proliferation process in the ischemically challenged region-at-risk after focal cerebral ischemia in the adult rat brain. A reversible photothrombotic ring s...

Adult Hippocampal Neurogenesis and Memory

Adult neurogenesis, a concept emergent in the late 1990s, is the generation of new neurons in the adult brain. This process occurs thank to cells who have this proliferative feature, named as Neural Stem Cells (NSCs). Neural Stem Cells (NSCs) are primary progenitors who can generate the two neural types (neurons and glia). Classically it was assumed that NSCs are only present in the embryo, but...